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Decanoyl-RVKR-CMK
CAS No. 150113-99-8
Decanoyl-RVKR-CMK ( —— )
产品货号. M30696 CAS No. 150113-99-8
Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥4586 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称Decanoyl-RVKR-CMK
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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产品描述Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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体外实验Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell.Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF. Cell Viability Assay Cell Line:HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.Concentration:35 and 70 μΜ.Incubation Time:7 days.Result:Peptide at 35 μM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
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体内实验——
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同义词——
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通路Microbiology/Virology
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靶点HIV
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number150113-99-8
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分子量744.42
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分子式C34H66ClN11O5
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纯度>98% (HPLC)
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溶解度water:1 mg/mL
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SMILES[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Garcia et al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595 PMID:
产品手册
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