DT2216 ( —— )

产品货号. M24077 CAS No. 2365172-42-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

DT2216
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).
产品描述

DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).DT2216 targets bcl-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation.
同义词

——
通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis;PROTAC;VHL
研究领域

——
适应症

——

CAS Number

2365172-42-3
分子量

1542.4
分子式

C77H96ClF3N10O10S4
纯度

>98% (HPLC)
溶解度

H2O : < 0.1 mg/mL (insoluble); DMSO : 25 mg/mL (16.21 mM; Need ultrasonic)
SMILES

CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(C1)CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN7CCN(C(CCCCCC(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(N[C@H](C9=CC=C(C%10=C(N=CS%10)C)C=C9)C)=O)=O)=O)=O)CC7)C=C5)=O)=O)C=C4)CC3
化学全称

——

1.Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.

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