DSP-1053
CAS No. 1176326-78-5
DSP-1053 ( DSP1053 )
产品货号. M10599 CAS No. 1176326-78-5
DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥12717 | 有现货 |
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50MG | ¥25758 | 有现货 |
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100MG | ¥34830 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称DSP-1053
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
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产品描述DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo.Depression Phase 1 Discontinued
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同义词DSP1053
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Neurological Disease
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适应症Depression
化学信息
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CAS Number1176326-78-5
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分子量660.62
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分子式C32H38BrNO7S
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称6-(2-{4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.
产品手册
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