DSP-1053 ( DSP1053 )

产品货号. M10599 CAS No. 1176326-78-5

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

DSP-1053
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively.
产品描述

DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively; inhibits serotonin transporter with IC50 of 2.74 nM and shows an intrinsic activity for 5-HT1A receptors of 70.0%; dose-dependently increases extracellular 5-HT levels in rat microdialysis at 3-10 mg/kg, demonstrates antidepressant-like effect in vivo.Depression Phase 1 Discontinued
同义词

DSP1053
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

Neurological Disease
适应症

Depression

CAS Number

1176326-78-5
分子量

660.62
分子式

C32H38BrNO7S
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

6-(2-{4-[4-Bromo-3-(2-methoxyethoxy)benzyl]piperidin-1-yl}ethyl)-2,3-dihydro-4H-chromen-4-one benzenesulfonate

1. Yoshinaga H, et al. Bioorg Med Chem. 2018 May 1;26(8):1614-1627.
2. Kato T, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00142.

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