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DHODH-IN-15
CAS No. 1364791-88-7
DHODH-IN-15 ( —— )
产品货号. M26156 CAS No. 1364791-88-7
DHODH-IN-15 is the hydroxyfuran analogue of A771726.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2373 | 有现货 |
|
| 5MG | ￥3621 | 有现货 |
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| 10MG | ￥5338 | 有现货 |
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| 25MG | ￥7995 | 有现货 |
|
| 50MG | ￥11178 | 有现货 |
|
| 100MG | ￥15309 | 有现货 |
|
| 500MG | ￥30699 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHODH-IN-15
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-15 is the hydroxyfuran analogue of A771726.
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产品描述DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.(In Vitro):DHODH-IN-15 is a hydroxyfuran analogue of A771726, in which the biphenyl skeleton does not carry any substituents. Turning to the derivative DHODH-IN-15, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, DHODH-IN-15 was found to bind in a BQN-like manner, ie, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. On 1D3G and 1UUO, in any case, no interaction of Tyr356 with Leflunomide was found, but when 2BXV was used as a docking target, a large part of this posture was found.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1364791-88-7
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分子量281.3
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分子式C15H11N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(Nc1ccc(cc1)-c1ccccc1)c1no[nH]c1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Issara-Amphorn et al. Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis. J Innate Immun. 2020;12(6):461-479.
产品手册
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