DHODH-IN-14
CAS No. 1364791-93-4
DHODH-IN-14 ( —— )
产品货号. M26155 CAS No. 1364791-93-4
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥2373 | 有现货 |
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5MG | ¥3637 | 有现货 |
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10MG | ¥5338 | 有现货 |
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25MG | ¥7995 | 有现货 |
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50MG | ¥11259 | 有现货 |
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100MG | ¥15228 | 有现货 |
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500MG | ¥30618 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称DHODH-IN-14
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
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产品描述DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.(In Vitro):DHODH-IN-14 is a hydroxyfuran analog of A771726, which contains a biphenyl scaffold with a fluorine substituent. Turning to the derivative DHODH-IN-14, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, it was found that DHODH-IN-14 was bound in a BQN-like manner, that is, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. Although it was not found on 1D3G and 1UUO that hydroxyfuran interacted with Tyr356 in a similar way to leflunomide, when 2BXV was used as a docking target, a large portion of such postures were found.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体E3 Ligase Ligand-Linker Conjugate
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研究领域——
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适应症——
化学信息
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CAS Number1364791-93-4
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分子量353.2
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分子式C15H7F4N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESFc1c(F)c(-c2ccccc2)c(F)c(F)c1NC(=O)c1no[nH]c1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
产品手册
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