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DHODH-IN-14

CAS No. 1364791-93-4

DHODH-IN-14 ( —— )

产品货号. M26155 CAS No. 1364791-93-4

DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥2373 有现货
5MG ¥3637 有现货
10MG ¥5338 有现货
25MG ¥7995 有现货
50MG ¥11259 有现货
100MG ¥15228 有现货
500MG ¥30618 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    DHODH-IN-14
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
  • 产品描述
    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.(In Vitro):DHODH-IN-14 is a hydroxyfuran analog of A771726, which contains a biphenyl scaffold with a fluorine substituent. Turning to the derivative DHODH-IN-14, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, it was found that DHODH-IN-14 was bound in a BQN-like manner, that is, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. Although it was not found on 1D3G and 1UUO that hydroxyfuran interacted with Tyr356 in a similar way to leflunomide, when 2BXV was used as a docking target, a large portion of such postures were found.
  • 同义词
    ——
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Dehydrogenase
  • 受体
    E3 Ligase Ligand-Linker Conjugate
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1364791-93-4
  • 分子量
    353.2
  • 分子式
    C15H7F4N3O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Fc1c(F)c(-c2ccccc2)c(F)c(F)c1NC(=O)c1no[nH]c1=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
产品手册
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