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DHODH-IN-13
CAS No. 1364791-86-5
DHODH-IN-13 ( —— )
产品货号. M26154 CAS No. 1364791-86-5
DHODH-IN-13 是 A771726 的羟基呋喃类似物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2373 | 有现货 |
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| 5MG | ￥3637 | 有现货 |
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| 10MG | ￥5338 | 有现货 |
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| 25MG | ￥7995 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHODH-IN-13
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-13 是 A771726 的羟基呋喃类似物。
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产品描述DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
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体外实验DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体E3 Ligase Ligand-Linker Conjugate
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研究领域——
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适应症——
化学信息
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CAS Number1364791-86-5
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分子量273.171
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分子式C10H6F3N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESFC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
