DHODH-IN-11 ( —— )

产品货号. M22430 CAS No. 1263303-95-2

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产品名称

DHODH-IN-11
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).
产品描述

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.
同义词

——
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

DHODH
研究领域

——
适应症

——

1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.

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