DB772 ( —— )

产品货号. M33978 CAS No. 1451058-50-6

DB772 是一种牛病毒性腹泻病毒（BVDV）抑制剂。DB772 还具有抗朊病毒活性。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥1512	有现货
5MG	￥2334	有现货
10MG	￥4005	有现货
25MG	￥7718	有现货
50MG	￥12434	有现货
100MG	￥16677	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

DB772
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DB772 是一种牛病毒性腹泻病毒（BVDV）抑制剂。DB772 还具有抗朊病毒活性。
产品描述

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.
体外实验

DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM.DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia.Cell Viability Assay Cell Line:PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia Concentration:1 μM Incubation Time:4 days Result:Showed no significant effect on cell viability with 96.4% cell viability.Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Virus Protease
研究领域

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适应症

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化学信息

CAS Number

1451058-50-6
分子量

401.29
分子式

C20H18Cl2N4O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (24.92 mM; 超声助溶 )
SMILES

C1(N=C(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)N5)=C5C=CC=C1.Cl.Cl
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173.?

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