Crebanine ( Crebanine; Crebanin )

产品货号. M18308 CAS No. 25127-29-1

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HPLC

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产品名称

Crebanine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata.
产品描述

Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D.
同义词

Crebanine; Crebanin
通路

GPCR/G Protein
靶点

Antibacterial
受体

Others
研究领域

Cancer|Neurological Disease
适应症

——

CAS Number

25127-29-1
分子量

339.39
分子式

C20H21NO4
纯度

98%
溶解度

——
SMILES

CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC(=C5OC)OC)OCO3
化学全称

5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-, (R)-

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Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata.
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