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DS-2969b
CAS No. 2092352-48-0
DS-2969b ( DS 11960558 )
产品货号. M13279 CAS No. 2092352-48-0
DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DS-2969b
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL.
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产品描述DS-2969b (DS 11960558) is a novel orally active GyrB inhibitor, inhibits the supercoiling activity of C. difficile DNA gyrase with IC50 of 20 ng/mL; showes potent in vitro activity against C. difficile clinical isolates with MIC90 of 0.06 μg/mL, 2-, 32-, and 16-fold lower than the MIC90 of fidaxomicin, vancomycin, and metronidazole, respectively; demonstrates excellent in vivo activity against Clostridium difficile (CDI) model.Bacterial Infection Phase 1 Clinical
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同义词DS 11960558
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域Infection
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适应症Bacterial Infection
化学信息
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CAS Number2092352-48-0
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分子量428.94
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分子式C17H25ClN6O3S
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称4-chloro-5-ethyl-N-{(3S,4R)-1-[5-(2-hydroxypropan-2-yl)-1,3,4-thiadiazol-2-yl]-3-methoxypiperidin-4-yl}-1H-imidazole-2-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mathur T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02157-17.
2. Vandell AG, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02537-17.
2. Vandell AG, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.02537-17.
产品手册
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