Corin ( —— )

产品货号. M12765 CAS No. 1808113-09-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Corin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex.
产品描述

Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat; exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes; demonstrates effectivity in slowing tumor growth in a melanoma mouse xenograft model.
同义词

——
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

1808113-09-8
分子量

428.54
分子式

C26H28N4O2
纯度

>98% (HPLC)
溶解度

DMSO : 100 mg/mL 233.36 mM; H2O : < 0.1 mg/mL
SMILES

C1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N
化学全称

4-(4-((4-(2-aminocyclopropyl)phenyl)amino)-4-oxobutyl)-N-(2-aminophenyl)benzamide

1. Kalin JH, et al. Nat Commun. 2018 Jan 4;9(1):53.

计算器

产品手册

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