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Clarithromycin

CAS No. 81103-11-9

Clarithromycin ( A-56268 | Antibiotic A 56268 | TE 031 )

产品货号. M16030 CAS No. 81103-11-9

一种抗生素,可作为蛋白质合成抑制剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥405 有现货
200MG ¥462 有现货
500MG ¥599 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Clarithromycin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    一种抗生素,可作为蛋白质合成抑制剂。
  • 产品描述
    An antibiotic by acting as a protein synthesis inhibitor; binds to 23S rRNA, a component of the 50S subunit of the bacterial ribosome, thus inhibiting the translation of peptides; also attenuates autophagy in cancer cells.Bacterial Infection Approved(In Vitro):Clarithromycin produces a similar concentration-dependent block with an IC50 of 45.7 μM.Clarithromycin induces the formation of numerous intracytoplasmic vacuoles after 24?h, in all cell lines, especially in HCT116 cells. Prolonged treatment with Clarithromycin (40, 80, and 160?μM) alters cell proliferation and triggers apoptotic cell death in colorectal cancer (CRC) cells. Inhibition of cell proliferation is potentiated when Clarithromycin is re-added to the cells. In particular, 160?μM Clarithromycin, re-added after 48?h of incubation, produces an arrest of cell proliferation at 72?h. Similar effects are obtained in LS174T cells.Clarithromycin (80 and 160?μM; 48 hours) strongly increases the LC3-II/LC3-I ratio, in a dose- and time-dependent manner, with a maximum at 24?h of treatment. This effect is accompanied by a decrease of p62/SQSTM1.(In Vivo):Clarithromycin at 200 mg/kg has activity against four tested in vivo.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    A-56268 | Antibiotic A 56268 | TE 031
  • 通路
    GPCR/G Protein
  • 靶点
    Antibacterial
  • 受体
    50Sribosome|MRP1
  • 研究领域
    Infection
  • 适应症
    Bacterial Infection

化学信息

  • CAS Number
    81103-11-9
  • 分子量
    747.9534
  • 分子式
    C38H69NO13
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 7.4 mg/mL
  • SMILES
    CC[C@@H]1[C@@](C)(O)[C@H](O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(O1)=O)=O
  • 化学全称
    Erythromycin, 6-O-methyl-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Komatsu S, et al. Int J Oncol. 2012 Apr;40(4):1029-39. 2. Nakamura M, et al. Int J Oncol. 2010 Oct;37(4):815-20. 3. Altman JK, et al. Leuk Lymphoma. 2012 Jul;53(7):1255-6.
产品手册
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