Ceruletide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ceruletide 是一种有效的胆囊收缩素受体激动剂，也是一种安全有效的胆囊收缩剂。它对胆囊肌肉和胆管有直接的痉挛作用。Ceruletide在生物学和化学上与人体胃肠激素胆囊收缩素胰酶(CCK)和胃泌素II相同。

Ceruletide is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts.Ceruletide is same as biologically and chemically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction, while delaying gastric emptying and inhibiting motility in the proximal duodenum. Ceruletide in supramaximal but not in physiological doses activates NF-kappaB/Rel in vitro. This activation may induce a self-defending genetic program before the onset of cellular injury and may prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation.Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide SBA stimulation may perform as well as PP SBA stimulation in dogs with portosystemic shunt (PSS) and be more sensitive for the detection of hepatic dysfunction in dogs with upper respiratory disease (URD).

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Caerulein,Cerulein,FI-6934

GPCR/G Protein

Cholecystokinin Receptor

Cholecystokinin

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17650-98-5

1352.41

C58H73N13O21S2

>98% (HPLC)

H2O:100 mg/mL (73.94 mM); DMSO:96 mg/mL (70.98 mM)

NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc3cnc2ccccc23)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(OS(=O)(=O)O)cc4)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]5CCC(=O)N5)CCC(N)=O)[C@@H](C)O

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(-20℃)

With Ice Pack

≥ 2 years