Ceranib-2
CAS No. 1402830-75-4
Ceranib-2 ( 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one )
产品货号. M26102 CAS No. 1402830-75-4
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥721 | 有现货 |
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25MG | ¥1531 | 有现货 |
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50MG | ¥2535 | 有现货 |
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100MG | ¥4155 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ceranib-2
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells.
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产品描述Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.(In Vitro):In SKOV3 cells, Ceranib-2 (28 μM) decreases with 50% inhibition and induces the accumulation of multiple ceramide species. Ceranib-2 (10 nM-10 μM) inhibits cell proliferation and survival with an IC50 value of 0.73 μM. Ceranib-2 (0.75-1.5 μM) accumulates cells in the sub-G1. G2 and S phases of the cell cycle are concomitantly reduced in the number of cells in the G1 phase at the dose of 0.75 μM.(In Vivo):In female Balb/c mice, Ceranib-2 (20-50 mg/kg; i.p.) delays tumor growth without hematologic suppression in a syngeneic tumor model. Ceranib-2 (50 mg/kg; i.p.) increases the circulating levels, reaching a peak plasma concentration of approximately 40 μM at 2 hr.
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同义词3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
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通路Apoptosis
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靶点Apoptosis
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受体PEGs
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研究领域——
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适应症——
化学信息
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CAS Number1402830-75-4
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分子量381.4
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分子式C25H19NO3
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纯度>98% (HPLC)
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溶解度——
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SMILESCOc1ccc(\C=C\C(=O)c2c(-c3ccccc3)c3ccccc3[nH]c2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
产品手册
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