CeMMEC13 ( CeMMEC 13 )

产品货号. M12696 CAS No. 1790895-25-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CeMMEC13
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A selective TAF1 second bromodomain inhibitor with IC50 of 2.1 uM.
产品描述

A selective TAF1 second bromodomain inhibitor with IC50 of 2.1 uM; shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.
同义词

CeMMEC 13
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

TAF1
研究领域

Other Indications
适应症

——

CAS Number

1790895-25-8
分子量

336.30
分子式

C19H16N2O4
纯度

>98% (HPLC)
溶解度

DMSO: 62 mg/mL (184.3 mM); Ethanol: 6 mg/mL (17.83 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1=CC(N(C)C2=C1C=CC=C2)=O)NC3=CC=C(OCCO4)C4=C3
化学全称

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide

1. Sdelci S, et al. Nat Chem Biol. 2016 Jul;12(7):504-10.

计算器

产品手册

关联产品

CPI-637

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
GNE-886

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains.
BAY 299

BAY 299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 and the second bromodomain of TAF1 with IC50 of 6 nM and 13 nM, respectively.