
Capsazepine
CAS No. 138977-28-3
Capsazepine ( —— )
产品货号. M20641 CAS No. 138977-28-3
Capsazepine 是 TRPV1 受体的拮抗剂 ( IC50 : 562 nM)。 Capsazepine 可阻断由辣椒素(辣椒的活性成分)激活 TRPV1 离子通道引起的热痛感。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥389 | 有现货 |
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10MG | ¥616 | 有现货 |
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25MG | ¥1126 | 有现货 |
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50MG | ¥1887 | 有现货 |
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100MG | ¥3054 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Capsazepine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Capsazepine 是 TRPV1 受体的拮抗剂 ( IC50 : 562 nM)。 Capsazepine 可阻断由辣椒素(辣椒的活性成分)激活 TRPV1 离子通道引起的热痛感。
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产品描述Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.
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体外实验Capsazepine (50 μM) optimally enhances the upregulation of (death receptors) DRs without affecting cell viability HCT116 cells. Capsazepine (30-50 μM) induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells. Capsazepine (1-100 μM, 45 min preincubation) inhibits the evoked CGRP-LI release. Capsazepine (3-100 μM) prevents low pH- and capsaicin-induced CGRP-LI release from rat soleus muscle at concentrations which do not affect the release evoked by KCl. Capsazepine (3-100 μM, without 10 μM) produces a nonspecific inhibitory effect on CGRP-LI release from peripheral endings of the capsaicin-sensitive primary afferent neurone.
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体内实验Capsazepine (15 mg/kg, s.c.) prevents the increase in respiratory system resistance and decreases the increase in tissue damping during endotoxemia. Capsazepine attenuates lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点TRP/TRPV Channel
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受体TRPA1
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研究领域——
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适应症——
化学信息
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CAS Number138977-28-3
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分子量376.9
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分子式C19H21ClN2O2S
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纯度>98% (HPLC)
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溶解度DMSO:50 mg/mL (132.66 mM)
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SMILESOc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
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化学全称N-[2-(4-Chlorophenyl)ethyl]-1345-tetrahydro-78-dihydroxy-2H-2-benzazepine-2-carbothioamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yang MH Jung SH Sethi Get al.Pleiotropic Pharmacological Actions of Capsazepine a Synthetic Analogue of Capsaicin against Various Cancers and Inflammatory Diseases[J].Molecules. 2019 Mar 12;24(5). pii: E995.
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