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RN-1734
CAS No. 946387-07-1
RN-1734 ( —— )
产品货号. M20811 CAS No. 946387-07-1
RN-1734是选择性TRPV4通道拮抗剂（hTRPV4、mTRPV4和rTRPV4的IC50分别为2.3 μM、5.9 μM、3.2 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥267 | 有现货 |
|
| 5MG | ￥413 | 有现货 |
|
| 10MG | ￥599 | 有现货 |
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| 25MG | ￥1320 | 有现货 |
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| 50MG | ￥2244 | 有现货 |
|
| 100MG | ￥3345 | 有现货 |
|
| 500MG | ￥7590 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称RN-1734
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RN-1734是选择性TRPV4通道拮抗剂（hTRPV4、mTRPV4和rTRPV4的IC50分别为2.3 μM、5.9 μM、3.2 μM）。
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产品描述RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM5.9 μM3.2 μM for hTRPV4 ?mTRPV4 and rTRPV4respectively).
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体外实验Apoptosis Analysis Cell Line: Microglial cells Concentration:27 hours Incubation Time:10μM Result:Significantly decreased the percentage of cleaved-caspase 3 positive cells.Western Blot Analysis Cell Line:Microglial cells Concentration:27 hours Incubation Time:10 μM esult:Alleviated CM (with LPS only)-induced decreases in CNP.
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体内实验Animal Model:CPZ-induced demyelination mouse model (C57BL/6 male mice)Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)Administration:Microinjector pump for 5 weeks Result:Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点TRP/TRPV Channel
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受体hTRPV4
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研究领域——
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适应症——
化学信息
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CAS Number946387-07-1
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分子量353.31
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分子式C14H22Cl2N2O2S
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纯度>98% (HPLC)
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溶解度DMSO:50 mg/mL (141.52 mM)
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SMILESCC(C)NCCN(C(C)C)S(=O)(=O)c1ccc(Cl)cc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Meiying Liu Xuan et al. TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination.[J]. Frontiers in cellular neuroscience 2018.
