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CUDC-427
CAS No. 1446182-94-0
CUDC-427 ( —— )
产品货号. M33326 CAS No. 1446182-94-0
CUDC-427 (GDC-0917) 是一种高效的 IAP 抑制剂，常用于各种癌症的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥543 | 有现货 |
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| 5MG | ￥791 | 有现货 |
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| 10MG | ￥1316 | 有现货 |
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| 25MG | ￥2260 | 有现货 |
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| 50MG | ￥3237 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CUDC-427
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CUDC-427 (GDC-0917) 是一种高效的 IAP 抑制剂，常用于各种癌症的研究。
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产品描述CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.
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体外实验GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 μM (56.5 ng/mL).
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体内实验GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species.
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同义词——
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通路Apoptosis
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靶点IAP
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受体IAP
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研究领域——
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适应症——
化学信息
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CAS Number1446182-94-0
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分子量564.7
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分子式C29H36N6O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (88.54 mM; 超声助溶 )
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SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)Nc1sc(nc1-c1ccccc1)-c1ncco1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wong H, et al. Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. Drug Metab Dispos. 2013 Dec;41(12):2104-13.?
