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CUDC-101
CAS No. 1012054-59-9
CUDC-101 ( CUDC101;CUDC 101 )
产品货号. M10074 CAS No. 1012054-59-9
A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥1021 | 有现货 |
|
| 50MG | ￥1677 | 有现货 |
|
| 100MG | ￥2989 | 有现货 |
|
| 500MG | ￥7169 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CUDC-101
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
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产品描述A potent, multi-targeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively; Exhibits efficient antiproliferative activity with greater potency (IC50<1 uM) than Vorinostat (SAHA), Erlotinib, Lapatinib; Promotes tumor regression or inhibition in various cancer xenograft models including NSCLC, liver, breast, head and neck, colon, and pancreatic cancers. Solid TumorsPhase 1 Discontinued
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同义词CUDC101;CUDC 101
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体EGFR;HDAC;HDAC1;HDAC10;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9;HER2
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number1012054-59-9
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分子量434.49
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分子式C24H26N4O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NO)CCCCCCOC1=CC2=C(NC3=CC=CC(C#C)=C3)N=CN=C2C=C1OC
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化学全称Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cai X, et al. J Med Chem. 2010 Mar 11;53(5):2000-9.
2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.
3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.
2. Lai CJ, et al. Cancer Res. 2010 May 1;70(9):3647-56.
3. Wang J, et al. Mol Cancer Ther. 2013 Jun;12(6):925-36.
产品手册
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