CU-CPD107

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CU-CPD107 是一种有效的选择性 toll-like receptor (TLR 8) 激动剂。CU-CPD107 抑制 TLR8 信号通路。CU-CPD107 在 ssRNA 存在下转化为协同激动剂活性并诱导 TLR8 信号转导。CU-CPD107 抑制促炎因子表达，避免 ssRNA 存在时产生的免疫反应。

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.

CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7?μM.CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA.CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels.

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Immunology/Inflammation

TLR

TLR

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2573912-32-8

400.25

C16H21IN2O2

>98% (HPLC)

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C(C(C)(C)O)N1C(=C(I)N=C1COCC)C2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years