CTEP
CAS No. 871362-31-1
CTEP ( RO4956371; RO-4956371; RO 4956371; CTEP )
产品货号. M17635 CAS No. 871362-31-1
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥421 | 有现货 |
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5MG | ¥656 | 有现货 |
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10MG | ¥1150 | 有现货 |
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25MG | ¥2017 | 有现货 |
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50MG | ¥3645 | 有现货 |
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100MG | ¥4957 | 有现货 |
|
500MG | ¥10692 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CTEP
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.
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产品描述CTEP, also known as RO4956371, is a potent, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM. CTEP binds mGlu5 with low nanomolar affinity and shows >1000-fold selectivity when tested against 103 targets, including all known mGlu receptors. CTEP penetrates the brain with a brain/plasma ratio of 2.6 and displaces the tracer ABP688 in vivo in mice from brain regions expressing mGlu5 with an average ED(50) equivalent to a drug concentration of 77.5 ng/g in brain tissue.
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同义词RO4956371; RO-4956371; RO 4956371; CTEP
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体mGluR5
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number871362-31-1
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分子量391.77
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分子式C19H13ClF3N3O
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纯度98%
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溶解度DMSO : ≥ 100 mg/mL. 255.25 mM; H2O : < 0.1 mg/mL
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SMILESCC1=NC(C#CC2=CC=NC(Cl)=C2)=C(C)N1C1=CC=C(OC(F)(F)F)C=C1
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化学全称2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lindemann L, et al. J Pharmacol Exp Ther, 2011, 339(2), 474-486.
产品手册
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