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CTEP

CAS No. 871362-31-1

CTEP ( RO4956371; RO-4956371; RO 4956371; CTEP )

产品货号. M17635 CAS No. 871362-31-1

CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥421 有现货
5MG ¥656 有现货
10MG ¥1150 有现货
25MG ¥2017 有现货
50MG ¥3645 有现货
100MG ¥4957 有现货
500MG ¥10692 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CTEP
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.
  • 产品描述
    CTEP, also known as RO4956371, is a potent, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM. CTEP binds mGlu5 with low nanomolar affinity and shows >1000-fold selectivity when tested against 103 targets, including all known mGlu receptors. CTEP penetrates the brain with a brain/plasma ratio of 2.6 and displaces the tracer ABP688 in vivo in mice from brain regions expressing mGlu5 with an average ED(50) equivalent to a drug concentration of 77.5 ng/g in brain tissue.
  • 同义词
    RO4956371; RO-4956371; RO 4956371; CTEP
  • 通路
    Endocrinology/Hormones
  • 靶点
    5-HT Receptor
  • 受体
    mGluR5
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    871362-31-1
  • 分子量
    391.77
  • 分子式
    C19H13ClF3N3O
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 100 mg/mL. 255.25 mM; H2O : < 0.1 mg/mL
  • SMILES
    CC1=NC(C#CC2=CC=NC(Cl)=C2)=C(C)N1C1=CC=C(OC(F)(F)F)C=C1
  • 化学全称
    2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Lindemann L, et al. J Pharmacol Exp Ther, 2011, 339(2), 474-486.
产品手册
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