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首页- Products - Angiogenesis - PDE - CRT0273750

CRT0273750

CAS No. 1979939-16-6

CRT0273750 ( CRT 0273750; CRT-0273750 )

产品货号. M27971 CAS No. 1979939-16-6

CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ￥640 有现货
5MG ￥988 有现货
10MG ￥1596 有现货
25MG ￥3621 有现货
50MG ￥5338 有现货
100MG ￥7606 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    CRT0273750
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
  • 产品描述
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.(In Vitro):CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM).(In Vivo):CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase.CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg.
  • 同义词
    CRT 0273750; CRT-0273750
  • 通路
    Angiogenesis
  • 靶点
    PDE
  • 受体
    Cannabinoid Receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1979939-16-6
  • 分子量
    502.9
  • 分子式
    C25H22ClF3N4O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Everett RM, et al. Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced acute tubular necrosis. Fundam Appl Toxicol. 1993 Jul;21(1):59-65.
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