CNX-774 ( CNX774; CNX 774; CNX-774 )

产品货号. M17187 CAS No. 1202759-32-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CNX-774
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
产品描述

CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.
同义词

CNX774; CNX 774; CNX-774
通路

Apoptosis
靶点

Apoptosis
受体

BTK
研究领域

Cancer
适应症

——

CAS Number

1202759-32-7
分子量

499.5
分子式

C26H22FN7O3
纯度

98%
溶解度

DMSO : ≥ 45 mg/mL. 90.09 mM
SMILES

c1c(ccc(c1)Oc1ccnc(c1)C(=O)NC)Nc1nc(c(cn1)F)Nc1cccc(c1)NC(=O)C=C
化学全称

4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide

1. Labenski M. 17th North Am Meet Int Soc Study Xenobiot (ISSX) 2011. Abst. P211.

计算器

产品手册

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