CIQ

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CIQ 是含有 NR2C 或 NR2D 亚基的 NMDA 受体亚基选择性增强剂。 EC50 值：NR2C 为 2.7 μM，NR2D 为 2.8 μM。

CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.(In Vitro):CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models. NMDA receptor CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively). It has no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses.

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Membrane Transporter/Ion Channel

NMDAR

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486427-17-2

467.95

C26H26ClNO5

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (106.85 mM)

COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1

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(-20℃)

With Ice Pack

≥ 2 years