Glypromate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Glypromate 是一种神经保护剂，是一种弱 NMDA 受体激动剂。

Glypromate is a neuroprotective agent is a weak NMDA receptor agonist.

Gly-Pro-Glu (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release.Gly-Pro-Glu (1-1000 μM) shows an inhibition of L-[3H]glutamate binding with an IC50 value of 14.7 μM.

Gly-Pro-Glu (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.. Animal Model:Ovariectomized rats with Abeta25-35 injection Dosage:300 mg Administration:Intraperitoneal injection; 300 mg per day; on day 0, 6 and 12 Result:Recovered Abeta25-35-induced the reduction of somatostatin (SRIF) content and SRIF receptor density, and reduced the inhibitory effect of SRIF on adenylyl cyclase activity.

Gly-Pro-Glu

Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

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32302-76-4

301.3

C12H19N3O6

>98% (HPLC)

In Vitro:?DMSO : 66.67 mg/mL (221.27 mM)

NCC(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)O

glycyl-L-prolyl-L-glutamic acid

(-20℃)

With Ice Pack

≥ 2 years