CD73-IN-4 ( —— )

产品货号. M24001 CAS No. 2216764-29-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CD73-IN-4
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CD73-IN-4 是一种有效的选择性亚甲基膦酸 CD73 抑制剂。
产品描述

CD73-IN-4 is a potent and selective methylenephosphonic acid?CD73?inhibitor.
体外实验

CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

CD73
研究领域

——
适应症

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CAS Number

2216764-29-1
分子量

463.81
分子式

C16H23ClN5O7P
纯度

>98% (HPLC)
溶解度

DMSO:125 mg/mL?(265.19 mM;?Need ultrasonic)
SMILES

O[C@H]1[C@H](N2N=CC3=C(NC4CCCC4)N=C(Cl)N=C32)O[C@H](COCP(O)(O)=O)[C@H]1O
化学全称

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1.Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.

计算器

产品手册

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