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2614W94

CAS No. 205187-35-5

2614W94 ( —— )

产品货号. M26022 CAS No. 205187-35-5

2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥4026 有现货
10MG ¥5856 有现货
25MG ¥9153 有现货
50MG ¥12312 有现货
100MG ¥16038 有现货
500MG ¥32157 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    2614W94
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.
  • 产品描述
    2614W94 is a selective, competitive, and reversible inhibitor of monoamine oxidase-A with IC50 of 5 nM and Ki of 1.6 nM with serotonin as a substrate.(In Vitro):2614W94 (30 nM) shows no inhibition of MAO-B.(In Vivo):In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Alkyl-Chain
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    205187-35-5
  • 分子量
    344.3
  • 分子式
    C15H11F3O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CC(Oc1ccc2c(Oc3ccccc3S2(=O)=O)c1)C(F)(F)F
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
产品手册
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