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CCG-63802
CAS No. 620112-78-9
CCG-63802 ( —— )
产品货号. M26640 CAS No. 620112-78-9
CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥462 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1725 | 有现货 |
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| 50MG | ￥3200 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CCG-63802
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.
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产品描述CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.(In Vitro):CCG-63802 showed selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 ? 7. CCG-63802 inhibited the GTPase accelerating protein activity of RGS4.(In Vivo):The attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling was partially abrogated by administration of RGS4 inhibitor CCG-63802(0.5 mg/kg). The downregulation of RGS4 by CCG-63802 also significantly increased inflammatory cell accumulation and AHR, and increased levels of IL-4, IL-13, eotaxin, IFN-γ, and IL-17A in BALF, and total and OV-specific IgE in serum. The inhibitory effects of PGZ on the activations of ERK and Akt/mTOR signaling, and MMPs were apparently reversed by CCG-63802 administration.
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同义词——
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通路Others
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靶点Other Targets
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受体Microtubule/Tubulin
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研究领域——
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适应症——
化学信息
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CAS Number620112-78-9
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分子量450.5
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分子式C26H18N4O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESCc1cccc(Oc2nc3c(C)cccn3c(=O)c2\C=C(/C#N)c2nc3ccccc3s2)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gardner ER, et al. Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab. Invest New Drugs. 2012 Feb;30(1):90-7.
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