
CB-6644
CAS No. 2316817-88-4
CB-6644 ( —— )
产品货号. M26091 CAS No. 2316817-88-4
CB-6644 是 RUVBL1/2 复合物的选择性抑制剂,可阻断 RUVBL1/2 的 ATP 酶活性 (IC50 = 15 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥4690 | 有现货 |
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10MG | ¥6715 | 有现货 |
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25MG | ¥10206 | 有现货 |
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50MG | ¥13608 | 有现货 |
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100MG | ¥18468 | 有现货 |
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500MG | ¥37179 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CB-6644
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CB-6644 是 RUVBL1/2 复合物的选择性抑制剂,可阻断 RUVBL1/2 的 ATP 酶活性 (IC50 = 15 nM)。
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产品描述CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).(In Vitro):CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. In 123 cell lines such as HCT116, NCI-1975, and HT29 cells, CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).(In Vivo):Administration of oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226, CB-6644 has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.
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体外实验Cell Viability Assay Cell Line:123 cell lines such as HCT116, NCI-1975, and HT29 cells Concentration:0.001, 0.01, 0.1, 1, and 10 μM Incubation Time:72 hours Result:Potently killed cells with an EC50 range of 41 to 785 nM.
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体内实验Animal Model:SCID-beige mice bearing human tumor xenografts derived from either Burkitt’s lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines Dosage:150 mg/kg Administration:Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226 Result:There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2316817-88-4
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分子量573.06
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分子式C29H34ClFN4O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (174.50 mM)
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SMILESCCOc1cc(F)c(Cl)cc1C(=O)NCC(C)(C)CC(=O)Nc1c(COC)n2CCCc3ccccc3-n2c1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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