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CB-6644

CAS No. 2316817-88-4

CB-6644 ( —— )

产品货号. M26091 CAS No. 2316817-88-4

CB-6644 是 RUVBL1/2 复合物的选择性抑制剂,可阻断 RUVBL1/2 的 ATP 酶活性 (IC50 = 15 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥4690 有现货
10MG ¥6715 有现货
25MG ¥10206 有现货
50MG ¥13608 有现货
100MG ¥18468 有现货
500MG ¥37179 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    CB-6644
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    CB-6644 是 RUVBL1/2 复合物的选择性抑制剂,可阻断 RUVBL1/2 的 ATP 酶活性 (IC50 = 15 nM)。
  • 产品描述
    CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).(In Vitro):CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. In 123 cell lines such as HCT116, NCI-1975, and HT29 cells, CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).(In Vivo):Administration of oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226, CB-6644 has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.
  • 体外实验
    Cell Viability Assay Cell Line:123 cell lines such as HCT116, NCI-1975, and HT29 cells Concentration:0.001, 0.01, 0.1, 1, and 10 μM Incubation Time:72 hours Result:Potently killed cells with an EC50 range of 41 to 785 nM.
  • 体内实验
    Animal Model:SCID-beige mice bearing human tumor xenografts derived from either Burkitt’s lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines Dosage:150 mg/kg Administration:Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226 Result:There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2316817-88-4
  • 分子量
    573.06
  • 分子式
    C29H34ClFN4O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (174.50 mM)
  • SMILES
    CCOc1cc(F)c(Cl)cc1C(=O)NCC(C)(C)CC(=O)Nc1c(COC)n2CCCc3ccccc3-n2c1=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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