CAY10602

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CAY10602 是一种 SIRT1 激活剂。 CAY10602 源自对能够增加 SIRT1 介导的 SIRT1 特异性底物脱乙酰作用的化合物的高通量筛选。

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.

Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.

——

CAY10602 | CAY-10602 | CAY 10602

Others

Other Targets

SIRT1

——

——

374922-43-7

418.44

C22H15FN4O2S

>98% (HPLC)

DMSO : 100 mg/mL 238.98 mM

Fc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1

1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine

(-20℃)

With Ice Pack

≥ 2 years