GIBH-130 ( GIBH 130;GIBH130 )

产品货号. M11012 CAS No. 1252608-59-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GIBH-130
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM).
产品描述

A novel inhibitor of neuroinflammation, suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC50=3.4 nM); modulates the release of detrimental proinflammatory cytokines; exhibits in vivo efficacy of cognitive impairment in both β amyloid-induced and APP/PS1 double transgenic Alzheimer's murine models.Alzheimer's Disease Phase 1 Clinical
同义词

GIBH 130;GIBH130
通路

Others
靶点

Other Targets
受体

IL-1β
研究领域

Neurological Disease
适应症

Alzheimer Disease

CAS Number

1252608-59-5
分子量

360.42
分子式

C20H20N6O
纯度

>98% (HPLC)
溶解度

< 1 mg/ml refers to the product slightly soluble or insoluble
SMILES

O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3
化学全称

(4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone

1. Zhou W, et al. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.

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产品手册

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