C188-9（b）

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.

C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner.

C188-9; C 188-9; C-188-9

Others

Other Targets

STAT3

Cancer

——

432001-19-9

471.52

C27H21NO5S

98%

DMSO : ≥ 62 mg/mL; 131.49 mM

O=S(=O)(Nc4cc(c1c2ccccc2ccc1O)c(O)c3ccccc34)c5ccc(OC)cc5

N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years