C188-9（b） ( C188-9; C 188-9; C-188-9 )

产品货号. M18547 CAS No. 432001-19-9

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Datasheet

HNMR

HPLC

MSDS

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产品名称

C188-9（b）
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

C188-9 is a Stat3 inhibitor with an IC50 of 4-7 μM.
产品描述

C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner.
同义词

C188-9; C 188-9; C-188-9
通路

Others
靶点

Other Targets
受体

STAT3
研究领域

Cancer
适应症

——

1.Redell MS, et al. Blood. 2011 May 26;117(21):5701-9.

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