C-82

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

C-82 是一种特异性 CBP/β-catenin 拮抗剂。它抑制 β-catenin 和 CBP 之间的结合，并增加 β-catenin 和 p300 之间的结合。

C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.(In Vitro):C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs.(In Vivo):PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile.

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Chromatin/Epigenetic

Epigenetic Reader Domain

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1422253-37-9

578.673

C33H34N6O4

>98% (HPLC)

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[H][C@]12[C@H](C)N(Cc3cccc4cccnc34)C(=O)[C@H](Cc3ccc(O)cc3)N1C(=O)CN(C)N2C(=O)NCc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years