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UMB298
CAS No. 2266569-73-5
UMB298 ( —— )
产品货号. M24031 CAS No. 2266569-73-5
UMB298 是一种有效的选择性 CBP/P300 bromodomain 抑制剂。 UMB298 抑制 BRD4，IC50 为 5193nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2357 | 有现货 |
|
| 10MG | ￥3904 | 有现货 |
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| 25MG | ￥6391 | 有现货 |
|
| 50MG | ￥8748 | 有现货 |
|
| 100MG | ￥11988 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称UMB298
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UMB298 是一种有效的选择性 CBP/P300 bromodomain 抑制剂。 UMB298 抑制 BRD4，IC50 为 5193nM。
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产品描述UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
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体外实验UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth.UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. Cell Viability Assay Cell Line:MOLM13 and MM cells Concentration:0.01~10 μM Incubation Time:50 days Result:Inhibited cells growth.Western Blot Analysis Cell Line:MOLM13 cells Concentration:1~10 μM Incubation Time:2 hours Result:Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.RT-PCR Cell Line:MOLM13 cells Concentration:3 μM Incubation Time:2 hours Result:Down-regulated MYC expression.
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体内实验——
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同义词——
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通路Chromatin/Epigenetic
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靶点Epigenetic Reader Domain
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受体BRD4
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研究领域——
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适应症——
化学信息
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CAS Number2266569-73-5
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分子量479.01
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分子式C27H31ClN4O2
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纯度>98% (HPLC)
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溶解度DMSO:20mg/ml(41.75mM; need ultrasonic)
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SMILESCC1=C(C2=CC3=NC(CCC4=CC=C(OC)C(Cl)=C4)=C(NC5CCCCC5)N3C=C2)C(C)=NO1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors[J]. Journal of medicinal chemistry, 64(9):5787-5801.
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