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Bufotaline

CAS No. 471-95-4

Bufotaline ( —— )

产品货号. M18583 CAS No. 471-95-4

蟾蜍碱是蟾蜍的一种有毒分泌物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥953 有现货
10MG ¥1588 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Bufotaline
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    蟾蜍碱是蟾蜍的一种有毒分泌物。
  • 产品描述
    Bufotaline is a kind of poisonous secretions of toads.
  • 体外实验
    Bufotalin (0.1-2.5 μM; 12-96 hours) treatment dose- and time-dependently inhibits MG-63 osteoblastoma cell survival. Bufotalin (0.5-2.5 μM; 48 hours) treatment dose-dependently increases the percentage of Annexin V positive cells (apoptotic cells) and caspase-12 activity in MG-63 cells. Bufotalin-induced osteoblastoma cell apoptosis is associated with caspase-12 activation. Bufotalin (0.5-2.5 μM; 12 hours) treatment dose-dependently induces C/EBP homologous protein (CHOP) expression as well as PERK and IRE1 phosphorylation in MG-63 cells. Bufotalin induces endoplasmic reticulum (ER) stress activation in cells. Bufotalin treatment induces cell cycle arrest at G2/M phase through down-regulation of Aurora A, CDC25, CDK1, cyclin A and cyclin B1, as well as up-regulation of p53 and p21 in HepG2 cells. Bufotalin treatment also induces apoptosis which was accompanied by decrease in mitochondrial membrane potential, increases in intracellular calcium level and reactive oxygen species production, activations of caspase-9 and -3, cleavage of poly ADP-ribose polymerase (PARP) as well as changes in the expressions of bcl-2 and bax.Cell Viability Assay Cell Line:MG-63 osteoblastoma cells Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM Incubation Time:12 hours, 24 hours, 48 hours, 72 hours, 96 hours Result:Inhibited MG-63 osteoblastoma cell survival. Apoptosis Analysis Cell Line:MG-63 cells Concentration:0.5 μM, 1 μM, 2.5 μM Incubation Time:48 hours Result:Dose-dependently increased the percentage of Annexin V positive cells (apoptotic cells) and caspase-12 activity in MG-63 cells.Western Blot Analysis Cell Line:MG-63 cells Concentration:0.5 μM, 1 μM, 2.5 μM Incubation Time:12 hours Result:Dose-dependently induced CHOP expression as well as PERK and IRE1 phosphorylation in MG-63 cells.
  • 体内实验
    Bufotalin (0.5-1 mg/kg; intraperitoneal injection; twice daily; for 7 days) treatment shows a significantly reduced tumor growth in mice. Animal Model:SCID male mice (4-6 weeks old) injected with U2OS cells Dosage:0.5 mg/kg, 1 mg/kg Administration:Intraperitoneal injection; twice daily; for 7 days Result:Inhibited U2OS osteoblastoma cell growth in mice.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    471-95-4
  • 分子量
    444.56
  • 分子式
    C26H36O6
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 4.6 mg/mL; 10.35 mM
  • SMILES
    CC(=O)OC1CC2(C3CCC4CC(CCC4(C3CCC2(C1C5=COC(=O)C=C5)C)C)O)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

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