DTP3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DTP3 是一种选择性 MKK7/GADD45β 抑制剂，可抑制癌症选择性 NF-κB 生存途径。

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.

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Animal Model:6 to 8-week old male NOD/SCID mice (NOD.CB17-Prkdcscid/IcrCrl; Charles River) Dosage:14.5 mg/kg Administration:S.c.; daily; 28 days Result:Had shown a dramatic shrinkage of the tumors.Animal Model:CD1 male mice of 25-30 g Dosage:10 mg/kg (Pharmacokinetic Study) Administration:Intravenous injection Result:Had t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg.

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Others

Other Targets

GADD45β/MKK7

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1809784-29-9

525.6

C26H35N7O5

>98% (HPLC)

DMSO:100 mg/ml (190.26 mM); Ethanol:100 mg/ml (190.26 mM); Water:100 mg/ml (190.26 mM)

CC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N

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(-20℃)

With Ice Pack

≥ 2 years