Blonanserin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Blonanserin 是一种新型非典型抗精神病药，具有有效的多巴胺 D2 和血清素 5-HT2 受体拮抗剂特性。

Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 and serotonin 5-HT2 receptors antagonist properties.(In Vitro):Blonanserin exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3?receptor (Ki=0.494 nM). Blonanserin possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters.(In Vivo):Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice.

Blonanserin exerts some blockade of?α1-adrenergic receptors?(Ki=26.7?nM) and also shows significant affinity for the?D3?receptor?(Ki=0.494 nM). Blonanserin possesses low affinity for the?sigma receptor?(IC50=286 nM), but lacks significant?affinity?for numerous other sites including the?5-HT1A,?5-HT3,?D1,?α2-adrenergic,?β-adrenergic,?H1, and?mACh receptors?and the?monoamine transporters.

Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice. Animal Model:Mice received saline or phencyclidine once a day for 14 consecutive days Dosage:1 mg/kg Administration:Oral gavage; 1 mg/kg; 14 days Result:Had an effect on the social deficit in mice that received repeated PCP administration.

AD5423 | Lonasen

Endocrinology/Hormones

5-HT Receptor

5-HT2| D2

Neurological Disease

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132810-10-7

367.5

C23H30FN3

>98% (HPLC)

Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

CCN1CCN(CC1)C1=NC2=C(CCCCCC2)C(=C1)C1=CC=C(F)C=C1

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(-20℃)

With Ice Pack

≥ 2 years