021-51111890
购物车（）
sales@molnova.cn
Befiradol
CAS No. 208110-64-9
Befiradol ( F 13640;NLX 112 )
产品货号. M13242 CAS No. 208110-64-9
Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Befiradol
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
-
产品描述Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM; exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone; stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes; dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.Pain Discontinued
-
同义词F 13640;NLX 112
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Neurological Disease
-
适应症Pain
化学信息
-
CAS Number208110-64-9
-
分子量393.86
-
分子式C20H22ClF2N3O
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CN(C3=NC=C(C)C=C3)C)(F)CC2
-
化学全称(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79.
2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.
3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.
2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.
3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.
产品手册
关联产品
-
WAY-100635 maleate (...
WAY-100635 is a potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor.
-
KW-2478
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
-
5-HT7 agonist 1
5-HT7 agonist 1 is a selective agonist of 5-HT7 (IC50 = 222.93 nM).
