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Becampanel
CAS No. 188696-80-2
Becampanel ( AMP 397 )
产品货号. M12950 CAS No. 188696-80-2
Becampanel (AMP 397) 是 AMPA 受体 (AMPAR) 的有效竞争性拮抗剂，IC50 为 11 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Becampanel
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Becampanel (AMP 397) 是 AMPA 受体 (AMPAR) 的有效竞争性拮抗剂，IC50 为 11 nM。
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产品描述Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM; has anticonvulsant activity for the treatment of epilepsy, neuropathic pain and cerebral ischemia.Epilepsy Phase 2 Discontinued.
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体外实验Becampanel is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9.
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体内实验Becampanel is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. Becampanel has no genotoxic potential in vivo.
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同义词AMP 397
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通路Membrane Transporter/Ion Channel
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靶点iGluR
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受体iGluR
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研究领域Neurological Disease
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适应症Epilepsy
化学信息
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CAS Number188696-80-2
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分子量330.191
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分子式C10H11N4O7P
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C(NC2=C(C(CNCP(O)(O)=O)=CC([N+]([O-])=O)=C2)N1)=O
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化学全称((((7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)methyl)phosphonic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kwan P, et al. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.
2. Citraro R, et al. Expert Opin Ther Targets. 2014 Mar;18(3):319-34.
