Bazedoxifene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively.

Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.Bazedoxifene is a small molecular GP130 inhibitor, which binds to GP130 D1 domain.Bazedoxifene inhibits STAT3 phosphorylation induced by Il-6 and IL-11 in GP130/STAT3 pathway signaling.Bazedoxifene (10 μM-20 μM; 2 hours) inhibits STAT3 Phosphorylation Induced by cytokines in human pancreatic cancer cells.Bazedoxifene (5-20 μM; overnight) induces apoptosis in human pancreatic cancer cells.Bazedoxifene inhibits STAT3 nuclear translocation induced by IL-6.Bazedoxifene blocks the cells migration in pancreatic cancer cells by inhibition of GP130.

TSE-424

Endocrinology/Hormones

Estrogen Receptor/ERR

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198481-32-2

470.6

C30H34N2O3

>98% (HPLC)

DMSO : 100 mg/mL (212.49 mM; Need ultrasonic)

CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51

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(-20℃)

With Ice Pack

≥ 2 years