BVT-14225

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种选择性 11β-羟基类固醇脱氢酶 1 型 (11β-HSD1) 抑制剂，IC50 为 52 nM。

A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM; displays >200-fold selectivity over human and murine 11β-HSD2. reduces glucose levels in diabetic KKA(y) mice.Diabetes Preclinical.

Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.

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BVT14225 | BVT 14225

Metabolic Enzyme/Protease

11β-HSD

11β-HSD1

Metabolic Disease

Diabetes

376638-65-2

401.9313

C16H20ClN3O3S2

>98% (HPLC)

DMSO: ≥ 27 mg/mL

O=C(N(CC)CC)CC1=CSC(NS(=O)(C2=CC=CC(Cl)=C2C)=O)=N1

4-Thiazoleacetamide, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-

(-20℃)

With Ice Pack

≥ 2 years