BRL54443
CAS No. 57477-39-1
BRL54443 ( BRL 54443;BRL-54443 )
产品货号. M15098 CAS No. 57477-39-1
BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥389 | 有现货 |
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10MG | ¥616 | 有现货 |
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25MG | ¥1296 | 有现货 |
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50MG | ¥2041 | 有现货 |
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100MG | ¥3426 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称BRL54443
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
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产品描述BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively; shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM); selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes; significantly reduces formalin-induced flinching in rats.
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同义词BRL 54443;BRL-54443
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT1A;5-HT1B;5-HT1D;5-HT1E;5-HT1F
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number57477-39-1
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分子量230.31
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分子式C14H18N2O
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 51 mg/mL
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SMILESCN1CCC(C2=CNC3=C2C=C(O)C=C3)CC1
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化学全称1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.
2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.
3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.
2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.
3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.
产品手册
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