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BRL54443

CAS No. 57477-39-1

BRL54443 ( BRL 54443;BRL-54443 )

产品货号. M15098 CAS No. 57477-39-1

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥389 有现货
10MG ¥616 有现货
25MG ¥1296 有现货
50MG ¥2041 有现货
100MG ¥3426 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    BRL54443
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
  • 产品描述
    BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively; shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM); selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes; significantly reduces formalin-induced flinching in rats.
  • 同义词
    BRL 54443;BRL-54443
  • 通路
    Endocrinology/Hormones
  • 靶点
    5-HT Receptor
  • 受体
    5-HT1A;5-HT1B;5-HT1D;5-HT1E;5-HT1F
  • 研究领域
    Cardiovascular Disease
  • 适应症
    ——

化学信息

  • CAS Number
    57477-39-1
  • 分子量
    230.31
  • 分子式
    C14H18N2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 51 mg/mL
  • SMILES
    CN1CCC(C2=CNC3=C2C=C(O)C=C3)CC1
  • 化学全称
    1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.
2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.
3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.
产品手册
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