BMX-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMX-IN-1 (CAS 1431525-23-3) 是一种有效、选择性、不可逆的 BMX 激酶抑制剂，IC50 为 8 nM。

BMX-IN-1 (CAS 1431525-23-3)?is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM; also inhibits BTK with IC50 of 10.4 nM and displays 47-656-fold less potent for Blk, JAK3, EGFR, Itk, or Tec; inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with GI50 of 25 nM, exhibits antiproliferative activity in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines with GI50 of 2-5 uM.Prostate cancer Preclinical.

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BMX kinase inhibitor

Tyrosine Kinase

BMX Kinase

BMX Kinase

Cancer

Prostate Cancer

1431525-23-3

524.5903

C29H24N4O4S

>98% (HPLC)

10 mM in DMSO

C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CC=C(NS(=O)(C)=O)C=C5)=CC=C4N=C3)=O)=CC=C1C)=O

2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-

(-20℃)

With Ice Pack

≥ 2 years