BMS-986020

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS-986020 (BMS986020, AM-152) 是一种有效的、选择性的、口服的 LPA1 受体拮抗剂，用于治疗特发性肺纤维化。

BMS-986020 (BMS986020, AM-152) is a potent, selective, orally available LPA1 receptor antagonist for treating idiopathic pulmonary fibrosis.Cystic Fibrosis,Phase 2 Clinical(In Vitro):BMS-986020 (0.1-10 nM; pre-incubated) concentration-dependent displacement of [18F]BMT-083133 binding is observed in LPA1+ cells and lung sections. At 0.1 nM, the percent displacement in healthy mice, bleomycin mice, and IPF lungs is 18%, 24%, and 31%, respectively. At 10 nM, the percent displacement is 73%, 76%, and 64%, respectively.BMT-083133, a radioligand targeting LPA1 is developed as a translational research tool for assessment of lung LPA1 engagement of BMS-986020 using in vitro autoradiography (ARG).

BMS-986020 (0.1-10 nM; pre-incubated) concentration-dependent displacement of BMT-083133 binding is observed in LPA1+ cells and lung sections.?At 0.1 nM, the percent displacement in healthy mice, bleomycin mice, and IPF lungs is 18%, 24%, and 31%, respectively. At 10 nM, the percent displacement is 73%, 76%, and 64%, respectively.BMT-083133, a radioligand targeting LPA1 is developed as a translational research tool for assessment of lung LPA1 engagement of BMS-986020 using in vitro autoradiography (ARG).

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BMS 986020 | BMS986020 | AM-152 | AM152 | AM 152

GPCR/G Protein

Lysophospholipid Receptor

LPA1

Other Indications

Fibrosis

1257213-50-5

482.5271

C29H26N2O5

>98% (HPLC)

DMSO: ≥ 64 mg/mL

CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O

Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-

(-20℃)

With Ice Pack

≥ 2 years