BMS-309403

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效、选择性、细胞渗透性和口服活性的 FABP4（脂肪酸结合蛋白 4）抑制剂，Ki 小于 2 nM。

A potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM; improves endothelial function, phosphorylated and total eNOS and reduces plasma triglyceride levels but does not affect endothelium-independent relaxations in mice; exhibits an effective therapeutic activity against severe atherosclerosis and type 2 diabetes in mouse models.

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Animal Model:C57BL/6J mice (ApoE?/? mice)Dosage:15 mg/kg Administration:Chronic treatment ; daily for 6 weeks Result: Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE?/? mice.

BMS309403

Membrane Transporter/Ion Channel

FABP

FABP4|FABP3|FABP5

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300657-03-8

474.55

C31H26N2O3

>98% (HPLC)

100 mM in DMSO

CCc1c(c(nn1c2ccccc2c3cccc(c3)OCC(=O)O)c4ccccc4)c5ccccc5

2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid

(-20℃)

With Ice Pack

≥ 2 years