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BIX-01294
CAS No. 935693-62-2
BIX-01294 ( BIX 01294 | BIX01294 )
产品货号. M16693 CAS No. 935693-62-2
一种特异性小分子 G9a 组蛋白甲基转移酶抑制剂，IC50 为 1.7 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
|
| 5MG | ￥624 | 有现货 |
|
| 10MG | ￥964 | 有现货 |
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| 25MG | ￥1766 | 有现货 |
|
| 50MG | ￥2989 | 有现货 |
|
| 100MG | ￥4423 | 有现货 |
|
| 200MG | ￥6302 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BIX-01294
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种特异性小分子 G9a 组蛋白甲基转移酶抑制剂，IC50 为 1.7 uM。
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产品描述A specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM; weakly inhibits the closely related GLP enzyme (IC50=38 uM), no inhibition of the other HMTases (>45 uM); reduces H3K9me2 of bulk histones in several cell lines, enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts combined with BayK8644; also can reactivate expression of HIV-1 from latently infected cells.
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体外实验Cell Viability Assay Cell Line:Primary or recurrent tumor cells Concentration:2 μM Incubation Time:48 hours Result:Selectively inhibited recurrent tumor cell growth.
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体内实验Animal Model:Female MMTV-rtTA;TetO-Her2/neu (MTB;TAN) and TetO-Her2/neu (TAN) mice with recurrent or primary tumor cells Dosage:10 mg/kg Administration:IP; three times a week for 2 weeks Result:Significantly reduced tumor growth and tumor burden in recurrent tumor cells. Primary tumor growth was not inhibited. Slowed the growth of orthotopic recurrent tumors in athymic nude recipients.
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同义词BIX 01294 | BIX01294
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通路Chromatin/Epigenetic
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靶点HMTase
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受体HMTase
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研究领域Cancer
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适应症——
化学信息
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CAS Number935693-62-2
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分子量490.6403
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分子式C28H38N6O2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
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化学全称4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kubicek S, et al. Mol Cell. 2007 Feb 9;25(3):473-81.
2. Shi Y, et al. Cell Stem Cell. 2008 Nov 6;3(5):568-74.
3. Chang Y, et al. Nat Struct Mol Biol. 2009 Mar;16(3):312-7.
4. Imai K, et al. J Biol Chem. 2010 May 28;285(22):16538-45.
