MI-1481 ( MI1481 )

产品货号. M12955 CAS No. 1887178-64-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MI-1481
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MI-1481 (MI1481) 是 menin-MLL1 相互作用的高效抑制剂，IC50 为 3.6 nM。
产品描述

MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503; markedly reduces cell growth of murine bone marrow cells transformed with MLL-AF9 with GI50 of 34 nM, demonstrates potent on target activity in MLL leukemia cells with GI50 values of 36 nM in MV4;11 (harboring MLL-AF4 fusion protein) and 61 nM in MOLM13 (harboring MLL-AF9); downregulates the MLL fusion protein target genes, HOXA9 and MEIS1, at 100 nMin MV4;11 human MLL leukemia cells; strongly inhibits leukemia progression in vivo.
体外实验

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体内实验

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同义词

MI1481
通路

Chromatin/Epigenetic
靶点

HMTase
受体

HMTase
研究领域

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适应症

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CAS Number

1887178-64-4
分子量

597.661
分子式

C29H30F3N7O2S
纯度

>98% (HPLC)
溶解度

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SMILES

N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
化学全称

(S)-4methyl-1-((5-oxomorpholin-2-yl)methyl)-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile