BI-9564 ( BI 9564;BI9564 )

产品货号. M12927 CAS No. 1883429-22-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI-9564
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
产品描述

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM; displays 45-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1; blocks EOL-1 cell proliferation with EC50 of 0.8 uM, and displays antitumor activity in an AML xenograft model.
同义词

BI 9564;BI9564
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRD7;BRD9;CECR2
研究领域

Cancer
适应症

——

CAS Number

1883429-22-8
分子量

353.41
分子式

C20H23N3O3
纯度

>98% (HPLC)
溶解度

DMSO: 7.2 mg/mL (Need warming)
SMILES

O=C1N(C)C=C(C2=CC(OC)=C(CN(C)C)C=C2OC)C3=CC=NC=C13
化学全称

4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.
2. Krmer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

计算器

产品手册

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