BAMB-4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bamb-4 是一种高膜渗透性的肌醇 1,4,5-三磷酸-3-激酶 A (ITPKA) 抑制剂。它通过抑制ITPKA在肺肿瘤细胞中的促进转移作用发挥作用（ADP-Glo测定中IC50为37 μM）。

Bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA).?It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).

BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM.BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM.BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake.BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased V max .BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does notonly affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity.

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ITPKA-IN-C14

Others

Other Targets

ITPKA

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891025-25-5

252.27

C15H12N2O2

>98% (HPLC)

DMSO:39 mg/mL(154.6 mM)

Cc1ccc(cc1)C(=O)Nc1noc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years