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BAMB-4
CAS No. 891025-25-5
BAMB-4 ( ITPKA-IN-C14 )
产品货号. M22707 CAS No. 891025-25-5
Bamb-4 是一种高膜渗透性的肌醇 1,4,5-三磷酸-3-激酶 A (ITPKA) 抑制剂。它通过抑制ITPKA在肺肿瘤细胞中的促进转移作用发挥作用（ADP-Glo测定中IC50为37 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1239 | 有现货 |
|
| 5MG | ￥2017 | 有现货 |
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| 10MG | ￥3216 | 有现货 |
|
| 25MG | ￥5370 | 有现货 |
|
| 50MG | ￥7655 | 有现货 |
|
| 100MG | ￥10368 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BAMB-4
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Bamb-4 是一种高膜渗透性的肌醇 1,4,5-三磷酸-3-激酶 A (ITPKA) 抑制剂。它通过抑制ITPKA在肺肿瘤细胞中的促进转移作用发挥作用（ADP-Glo测定中IC50为37 μM）。
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产品描述Bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA).?It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).
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体外实验BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM.BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM.BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake.BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased V max .BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does notonly affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity.
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体内实验——
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同义词ITPKA-IN-C14
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通路Others
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靶点Other Targets
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受体ITPKA
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研究领域——
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适应症——
化学信息
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CAS Number891025-25-5
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分子量252.27
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分子式C15H12N2O2
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纯度>98% (HPLC)
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溶解度DMSO:39 mg/mL(154.6 mM)
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SMILESCc1ccc(cc1)C(=O)Nc1noc2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.
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