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Azeliragon
CAS No. 603148-36-3
Azeliragon ( TTP-488;PF-04494700 )
产品货号. M15253 CAS No. 603148-36-3
An orally bioavailable small molecule inhibitor of RAGE.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥267 | 有现货 |
|
| 5MG | ￥381 | 有现货 |
|
| 10MG | ￥648 | 有现货 |
|
| 25MG | ￥1199 | 有现货 |
|
| 50MG | ￥2130 | 有现货 |
|
| 100MG | ￥3459 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Azeliragon
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述An orally bioavailable small molecule inhibitor of RAGE.
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产品描述An orally bioavailable small molecule inhibitor of RAGE; inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine; has been shown to inhibit the binding of sRAGE to Aβ1-42 in a fluorescent polarization assay; reduces accumulation in the spleen of Aβ peptides and the expression of IL-6 and macrophage colony stimulating factor, reduces both inflammatory markers (TNF-α, TGF-β and IL-1) and CNS amyloid deposition.Alzheimer's Disease Phase 3 Clinical
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同义词TTP-488;PF-04494700
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通路Others
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靶点Other Targets
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受体RAGE
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number603148-36-3
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分子量532.12
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分子式C32H38ClN3O2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
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化学全称1-Propanamine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sabbagh MN, et al. Alzheimer Dis Assoc Disord. 2011 Jul-Sep;25(3):206-12.
2. Chen Y, et al. J Immunol. 2008 Sep 15;181(6):4272-8.
3. Burstein AH, et al. BMC Neurol. 2014 Jan 15;14:12.
2. Chen Y, et al. J Immunol. 2008 Sep 15;181(6):4272-8.
3. Burstein AH, et al. BMC Neurol. 2014 Jan 15;14:12.
产品手册
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